0183: A common polymorphism in CD40 Kozak sequence (-1C/T) is associated with myocardial infraction in the Tunisian male population

Common Genetic Variant of insig2 Gene rs7566605 Polymorphism Is Associated with Severe Obesity in North India

Background: Obesity is a very common disorder resulting from an imbalance between food intake and energy expenditure, and it has a substantial impact on the development of chronic diseases.  The aim of this study was to examine the association of INSIG2 (rs7566605) gene polymorphism with obesity and obesity associated phenotypes in North Indian subjects. Methods: The variants were investig...

RAGE p.82G>S Polymorphism Is Not Associated with the Risk of Multiple Sclerosis in Iranian Population

Background and Aims: Multiple sclerosis (MS) is known as a partially inheritable inflammatory autoimmune disease which involves the nervous system. Different studies suggest that immune dysregulation has an important role in the pathogenesis of MS, but its exact pathomechanism has not yet been explicated. The receptor for advanced glycation end products (RAGE) is a member of the immunoglobulin ...

Mir 143 rs353293 G>A Polymorphism is Not Associated with the Risk of Thyroid Cancer in the Iranian Population: A Case-Control Study

Background: Single nucleotide polymorphisms (SNPs) in the promoter region of miRNAs may disturb miRNAs processing, alter their expression, and ultimately affect an individual’s susceptibility to cancer. We conducted a case-control study to evaluate the association of rs353293 G>A with the risk of thyroid cancer in the Iranian population. Methods: 192 patients with thyroid cancer including (pap...

the study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region

چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...

The 763C>G Polymorphism of The Secretory PLA2IIa Gene Is Associated with Endometriosis in Iranian Women